Author: Uversky, Vladimir N
Title: The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins Document date: 2013_4_1
ID: 63gh2tg4_1
Snippet: Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) are new exciting members of the protein kingdom. 1, 2 They are highly abundant in nature, [3] [4] [5] [6] [7] possess numerous intriguing properties, 8 are intimately involved in various cellular processes [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] and are commonly found to be related to the pathogenesis of various diseases.....
Document: Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) are new exciting members of the protein kingdom. 1, 2 They are highly abundant in nature, [3] [4] [5] [6] [7] possess numerous intriguing properties, 8 are intimately involved in various cellular processes [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] and are commonly found to be related to the pathogenesis of various diseases. 13, [24] [25] [26] [27] [28] [29] The common theme of protein disorder-based functionality is recognition, and IDPs/IDPRs are frequently involved in complex protein-protein, protein-nucleic acid and protein-small molecule interactions.
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