Selected article for: "glutamic acid and protein protein"
Author: Uversky, Vladimir N
Title: The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins
  • Document date: 2013_4_1
    • ID: 63gh2tg4_49
    Snippet: This review illustrates that glutamic acid is differently used in ordered proteins/domains and in IDPs/IDPRs. In ordered proteins, glutamic acid residues are crucial for protein solubility and, being strategically placed within protein structure, play several structure-forming and structure-stabilizing roles. Here, glutamic acid is involved in electrostatic interactions and hydrogen bond formation, serves as an important α-helix former, and part.....
    Document: This review illustrates that glutamic acid is differently used in ordered proteins/domains and in IDPs/IDPRs. In ordered proteins, glutamic acid residues are crucial for protein solubility and, being strategically placed within protein structure, play several structure-forming and structure-stabilizing roles. Here, glutamic acid is involved in electrostatic interactions and hydrogen bond formation, serves as an important α-helix former, and participates in the α-helix cap formation. Glutamic acid is an important functional residue of ordered proteins, where it can be involved in the formation of specific electrostatic valves inside the pores of ion channels, or can play unique catalytic roles in the active sites

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