Author: William Binning; Aja E. Hogan-Cann; Diana Yae Sakae; Matthew Maksoud; Valeriy Ostapchenko; Mohammed Al-Onaizi; Sara Matovic; Wei-Yang Lu; Marco A. M. Prado; Wataru Inoue; Vania F. Prado
Title: Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice Document date: 2020_1_28
ID: ely200x3_95
Snippet: Interestingly, with the 4-days CNO treatment, the chronic activation of microglial hM3Dq alone no longer increased mRNA for inflammatory cytokine (TNF-α: Fig mice that do not express hM3Dq (CX3CR1CreER(+/-)) and were submitted to the same protocol CNO had no effect (Fig. 5E-G) , validating our findings that modulation of LPS-induced cytokine mRNA was attributable to hM3Gq signaling......
Document: Interestingly, with the 4-days CNO treatment, the chronic activation of microglial hM3Dq alone no longer increased mRNA for inflammatory cytokine (TNF-α: Fig mice that do not express hM3Dq (CX3CR1CreER(+/-)) and were submitted to the same protocol CNO had no effect (Fig. 5E-G) , validating our findings that modulation of LPS-induced cytokine mRNA was attributable to hM3Gq signaling.
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