Author: Cross, Robert W.; Mire, Chad E.; Borisevich, Viktoriya; Geisbert, Joan B.; Fenton, Karla A.; Geisbert, Thomas W.
Title: The Domestic Ferret (Mustela putorius furo) as a Lethal Infection Model for 3 Species of Ebolavirus Document date: 2016_8_15
ID: 6nu7rob8_23
Snippet: Infectious virus in plasma was not detected in any Ebolavirus group at day 2 after infection, suggesting that any viremia detected was owed to viral replication after exposure and not residual inoculum. By day 4, a mean of 4 log 10 PFU/mL, 3 log 10 PFU/mL, and 2 log 10 PFU/mL was first detected for ZEBOV, SEBOV, and BEBOV, respectively. Mean peak viremia levels (±SD) were 7.6 ± 0.38 log 10 PFU/mL on day 6 for ZEBOVinfected animals, 7.6 ± 0.29 .....
Document: Infectious virus in plasma was not detected in any Ebolavirus group at day 2 after infection, suggesting that any viremia detected was owed to viral replication after exposure and not residual inoculum. By day 4, a mean of 4 log 10 PFU/mL, 3 log 10 PFU/mL, and 2 log 10 PFU/mL was first detected for ZEBOV, SEBOV, and BEBOV, respectively. Mean peak viremia levels (±SD) were 7.6 ± 0.38 log 10 PFU/mL on day 6 for ZEBOVinfected animals, 7.6 ± 0.29 log 10 PFU/mL on day 7 for SEBOVinfected animals, and 6.9 ± 0.14 log 10 PFU/mL on day 8 for BEBOV-infected animals (Figure 1) .
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