Selected article for: "cross talk and NF κB activation inhibit"
Author: Heaton, Steven M.; Borg, Natalie A.; Dixit, Vishva M.
Title: Ubiquitin in the activation and attenuation of innate antiviral immunity
  • Document date: 2016_1_11
    • ID: 42d77vxf_34
    Snippet: NLRP4 has gained prominence as another negative regulator of multiple immune signaling pathways that is more widely expressed than NLRC5. NLRP4 was initially described to inhibit IKKα-mediated NF-κB activation (Fiorentino et al., 2002) . Upon RLR cascade activation, NLRP4 also inhibits IRF3 activation by recruiting the E3 deltex-4 (DTX4) to ubiquitinate and degrade TBK1 (Cui et al., 2012) , revealing yet another route for RLR/NLR cross-talk (Fi.....
    Document: NLRP4 has gained prominence as another negative regulator of multiple immune signaling pathways that is more widely expressed than NLRC5. NLRP4 was initially described to inhibit IKKα-mediated NF-κB activation (Fiorentino et al., 2002) . Upon RLR cascade activation, NLRP4 also inhibits IRF3 activation by recruiting the E3 deltex-4 (DTX4) to ubiquitinate and degrade TBK1 (Cui et al., 2012) , revealing yet another route for RLR/NLR cross-talk (Fig. 2, right) .

    Search related documents:
    Co phrase search for related documents
    • cascade activation and negative regulator: 1
    • cascade activation and NF κB activation: 1, 2, 3, 4
    • cascade activation and RLR cascade activation: 1, 2
    • cascade activation and signaling pathway: 1, 2, 3, 4
    • cross talk and negative regulator: 1
    • cross talk and NF κB activation: 1, 2, 3, 4, 5
    • cross talk and RLR cascade activation: 1
    • cross talk and RLR NLR cross talk: 1
    • cross talk and signaling pathway: 1, 2, 3, 4
    • negative regulator and NF κB activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • negative regulator and RLR cascade activation: 1
    • negative regulator and signaling pathway: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • NF κB activation and RLR cascade activation: 1
    • NF κB activation and signaling pathway: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25