Selected article for: "negative regulator and NF κB activation"
Author: Heaton, Steven M.; Borg, Natalie A.; Dixit, Vishva M.
Title: Ubiquitin in the activation and attenuation of innate antiviral immunity
  • Document date: 2016_1_11
    • ID: 42d77vxf_34
    Snippet: NLRP4 has gained prominence as another negative regulator of multiple immune signaling pathways that is more widely expressed than NLRC5. NLRP4 was initially described to inhibit IKKα-mediated NF-κB activation (Fiorentino et al., 2002) . Upon RLR cascade activation, NLRP4 also inhibits IRF3 activation by recruiting the E3 deltex-4 (DTX4) to ubiquitinate and degrade TBK1 (Cui et al., 2012) , revealing yet another route for RLR/NLR cross-talk (Fi.....
    Document: NLRP4 has gained prominence as another negative regulator of multiple immune signaling pathways that is more widely expressed than NLRC5. NLRP4 was initially described to inhibit IKKα-mediated NF-κB activation (Fiorentino et al., 2002) . Upon RLR cascade activation, NLRP4 also inhibits IRF3 activation by recruiting the E3 deltex-4 (DTX4) to ubiquitinate and degrade TBK1 (Cui et al., 2012) , revealing yet another route for RLR/NLR cross-talk (Fig. 2, right) .

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