Author: Zhou, ShengTao; Liu, Rui; Zhao, Xia; Huang, CanHua; Wei, YuQuan
Title: Viral proteomics: The emerging cutting-edge of virus research Document date: 2011_6_26
ID: 3ahamzjv_2
Snippet: Proteomics is an emerging high-throughput technology †Contributed equally to this work *Corresponding author (email: [email protected]; [email protected]) that complements genomics exploration to evaluate protein-protein interactions and cellular alterations on a global scale, allowing the discovery of previously unannotated connections. Progress in mass spectrometry-based proteomics strategies not only revolutionized the investigation of spec.....
Document: Proteomics is an emerging high-throughput technology †Contributed equally to this work *Corresponding author (email: [email protected]; [email protected]) that complements genomics exploration to evaluate protein-protein interactions and cellular alterations on a global scale, allowing the discovery of previously unannotated connections. Progress in mass spectrometry-based proteomics strategies not only revolutionized the investigation of specific proteins, but also enabled global protein expression analysis [2, 3] . However, proteome research is still somewhat held back by the intrinsically complicated nature of proteins, the heterogeneity in subcellular location of proteins, and the variable sensitivity in identifying less abundant proteins in the presence of highly abundant proteins [4, 5] . Recent advances in comparative proteomics and quantitative proteomics have addressed some of these drawbacks and have provided seminal weapons for protein investigation.
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