2017 ACVIM Forum Research Abstract Program

The strikingly high prevalence of specific CNAs in canine tumors is supportive of their biological relevance in CPT oncogenesis and progression. If the characteristic CNAs of whole chromosomal losses reflects a common oncogenic mechanism in human and canine CPTs, comparative cytogenetics and more detailed analysis of candidate genes within orthologous regions may provide insight into both novel and common pathways in choroid plexus tumor biology. Implants used in surgical vertebral stabilization are typically placed bicortically due to a theoretical increase in pullout strength and construct stiffness. Bicortical implants, however, have an increased risk of impingement of regional neurovascular structures. Recent studies involving cervical vertebrae suggested that monocortical pin/screw plate constructs tested in bending are biomechanically equivalent to bicortical constructs. There is no data directly comparing the pullout strength of each implant type/ method in canine lumbar vertebrae.