Selected article for: "Analysis software and copy number"
Title: 2017 ACVIM Forum Research Abstract Program
  • Document date: 2017_6_15
    • ID: ri2w5iby_117
    Snippet: LUS was useful in predicting CHF as the cause of cough in this study population, particularly among dogs with concurrent heart disease. LUS is a potentially valuable diagnostic tool to identify (and avoid misdiagnosis of) CHF in coughing dogs. Defining commonly occurring cytogenetic abnormalities in canine choroid plexus tumors (CPTs) is essential to an understanding of oncogenesis, and the definition of appropriate therapeutic strategies. We use.....
    Document: LUS was useful in predicting CHF as the cause of cough in this study population, particularly among dogs with concurrent heart disease. LUS is a potentially valuable diagnostic tool to identify (and avoid misdiagnosis of) CHF in coughing dogs. Defining commonly occurring cytogenetic abnormalities in canine choroid plexus tumors (CPTs) is essential to an understanding of oncogenesis, and the definition of appropriate therapeutic strategies. We used Illumina 173K HD SNP arrays to determine copy number alterations (CNAs) and allelic imbalances in 12 histologically confirmed spontaneous canine choroid plexus tumor samples (3 papillomas/CPP, 8 carcinomas/CPC, 1 recurrent CPP) and tumor matched normal tissue. Copy number calls and allelic events were determined by matched paired analysis using BioDiscovery Nexus Copy Number TM software.

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