Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_169
Snippet: PC-3 is overexpressed in canine intracranial neoplasms and in high grade human astrocytomas relative to normal brain tissues. Immortalized canine, human, and murine glioma cell lines show in vitro sensitivity to PAC-1 and radiation monotherapies at biologically relevant exposures. Six dogs (3 gliomas 3 meningiomas) received PAC-1 combinatorial therapies and achieved objective responses (1 complete response, 3 partial responses, 2 with stable dise.....
Document: PC-3 is overexpressed in canine intracranial neoplasms and in high grade human astrocytomas relative to normal brain tissues. Immortalized canine, human, and murine glioma cell lines show in vitro sensitivity to PAC-1 and radiation monotherapies at biologically relevant exposures. Six dogs (3 gliomas 3 meningiomas) received PAC-1 combinatorial therapies and achieved objective responses (1 complete response, 3 partial responses, 2 with stable disease).
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