Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_15
Snippet: The GWAS revealed the strongest association signal on Chromosome 17 (P = 7.7 9 10 À6 ), near the CTNNA2 gene, which codes for alpha-catenin. Fine mapping of CTNNA2 did not detect a mutation within the coding regions of the gene. However, Western blot analysis revealed a 53% decrease in normalized alpha-catenin levels and an 86% decrease in beta-catenin (P-Y142 isoform) compared to control samples. PRO-seq experiments did not reveal a clear signa.....
Document: The GWAS revealed the strongest association signal on Chromosome 17 (P = 7.7 9 10 À6 ), near the CTNNA2 gene, which codes for alpha-catenin. Fine mapping of CTNNA2 did not detect a mutation within the coding regions of the gene. However, Western blot analysis revealed a 53% decrease in normalized alpha-catenin levels and an 86% decrease in beta-catenin (P-Y142 isoform) compared to control samples. PRO-seq experiments did not reveal a clear signal for regulatory enhancers upstream of alpha-catenin near the highest association signal. The PRO-seq data additionally revealed genome-wide expression profiles for genes significantly up-or-down regulated (P < 0.05 after Bonferroni correction) in the DMVD sample. A > 2-fold change was noted in 187 genes; with functions such as wound healing, regulation of muscle contraction, and muscle structure development.
Search related documents:
Co phrase search for related documents- alpha catenin and blot analysis: 1
- alpha catenin and CTNNA2 gene: 1
- association signal and fine mapping: 1
- beta catenin and blot analysis: 1, 2
- beta catenin and CTNNA2 gene: 1
- blot analysis and control sample: 1
- blot analysis and expression profile: 1, 2, 3, 4, 5, 6
- control sample and expression profile: 1
Co phrase search for related documents, hyperlinks ordered by date