2017 ACVIM Forum Research Abstract Program

Nineteen dogs were assessed: 11 (57.89%) females and eight (42.11%) males with a mean age of 8.7 years. At Hypertriglyceridemia and elevated serum glucose were observed in dogs treated with chemotherapy associated with glucocorticoids. Further studies on these changes are necessary. In recent decades, the prevalence of feline hyperthyroidism (FHT) has increased significantly worldwide and is currently a major endocrine disease that causes high morbidity in middle-aged cats. Due to the lack of studies on this endocrine disease in Brazil, a retrospective study of stored serum samples from all cats older than eight years treated at the Veterinary Hospital of Anhembi Morumbi University (São Paulo, Brazil) was carried out from January 2013 to January 2015, regardless of the main complaint that led them to be treated at the service. Thyroid function was evaluated through total thyroxine (T4T) measurements. A total of 212 cat serum samples were sent to a private laboratory, where T4T was measured by radioimmunoassay (RIA). Of the 212 assessed serum samples, 3.30% confirmed feline hyperthyroidism, 59.91% were within the normal range and 36.79% were below the normal value, suggesting sick euthyroid syndrome. In 2.35% of the samples, T4T values were close to the upper limit value, which raises the possibility that these cats had FHT, but whose comorbidities at the time of blood collection reduced T4T values in blood serum. We conclude that even though the prevalence of FHT in the assessed group was shown to be discreet, this clinical suspicion should be part of the differential diagnosis in cats aged ≥ eight years. Endo-and exogenous hypercortisolemia is well known to associated with insulin resistance in dogs. However, the types of changes in the levels of hormones involved in maintaining the blood glucose levels of dogs with hypercortisolemia are unknown. The objective of this study was to assess whether insulin sensitivity and the factors regulating blood glucose levels in dogs are altered by chronic administration of hydrocortisone.