Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_204
Snippet: Conclusions: MCT1 and MCT4 are expressed in canine osteosarcoma. Drug combinations with synergistic activity are necessary to realize the full potential of MCT1/4 inhibition. Transitional cell carcinoma (TCC) is the most common neoplasia of the urinary tract in dogs. It tends to be locally invasive and has a moderate metastatic rate. Systemic medical therapy with a combination of a non-steroidal anti-inflammatory drug (NSAID) and a chemotherapeut.....
Document: Conclusions: MCT1 and MCT4 are expressed in canine osteosarcoma. Drug combinations with synergistic activity are necessary to realize the full potential of MCT1/4 inhibition. Transitional cell carcinoma (TCC) is the most common neoplasia of the urinary tract in dogs. It tends to be locally invasive and has a moderate metastatic rate. Systemic medical therapy with a combination of a non-steroidal anti-inflammatory drug (NSAID) and a chemotherapeutic agent is the current mainstay of treatment. Receptor tyrosine kinases (RTKs) play an important role in promoting cell growth, differentiation and regulation of cell function. RTK inhibitor Palladia has been used anecdotally to treat TCC.
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