2017 ACVIM Forum Research Abstract Program

l lymphoma. Higher expression of Ki-67 was observed in those animals affected by lymphoblastic or B-cell and is related to low therapeutic response and shorter survival time. is typically caused by a growth-hormone (GH) secreting pituitary adenoma and is thought to be a common cause of feline diabetes mellitus. Medical pituitary inhibition has been challenging in some humans and cats with this condition. This could be related to variable expression of somatostatin (SSTR) and dopamine (DR) receptor expression. There are five different SSTR subtypes (SSTR1-5) and five different subtypes of DRs, with D2R being the predominant DR subtype in the human pituitary. Pasireotide, a somatostatin analogue with high binding affinity to SSTR1, SSTR2 and SSTR5, is effective at controlling GH secretion in feline acromegalics but somatostatin analogues with high binding affinity to SSTR2 (octreotide and lanreotide) are not.