2017 ACVIM Forum Research Abstract Program

In conclusion, we showed a high degree of variability within individual dogs as well as with storage methods. This data improves our understanding of SCFA analysis, and the potential interpretation of SCFA in studies of chronic enteropathies in dogs. Beyond their role in digestion, bile acids also act as systemic signaling modulators of several pathways involving glucose and lipid metabolism and play an anti-inflammatory role through the activation of nuclear and G-protein coupled receptors (i.e., GPBAR-1 or TGR5). TGR5 expression has been demonstrated in many gastrointestinal tissues of humans and laboratory animals. The aim of this study was to evaluate the immunohistochemical distribution of TGR5 receptors in the gastrointestinal tract of dogs.