2009 H1N1 Influenza and Experience in Three Critical Care Units

Teke, Turgut; Coskun, Ramazan; Sungur, Murat; Guven, Muhammed; Bekci, Taha T; Maden, Emin; Alp, Emine; Doganay, Mehmet; Erayman, Ibrahim; Uzun, Kursat

Of the 61 patients, all of them received oseltamivir. The mean time from the onset of illness to the initiation of antiviral therapy was 7.4±4.17 days (range, 1 to 22 days); 2 of the patients received antiviral therapy within 48 hours after the onset of symptoms. Antiviral therapy was started before admission in 4 patients, on admission in 55 patients, within 48 hours after admission in 2 patients. There was significant difference according to the time from the onset of illness to the initiation of antiviral therapy between nonsurvivors and survivors (p<0.05). Initiation time of antiviral treatment was earlier in survivors compared to nonsurvivors. All patients received antibiotics. Antibiotic therapy was started before admission in 32 patients and on admission in 29 patients. Patients received a mean of two different antibiotics (range, one to five); 81% of the patients received more than one antibiotic. Commonly used antibiotics included moxifloxacin (in 19 patients), linezolid (in 14 patients), ampicilline-sulbactam (in 13 patients), clarithromycin (in 13 patients), piperacillin-tazobactam (in 12 patients), imipenem (in 11 patients), third generation cephalosporin (in 9 patients), vancomycin (in 2 patients), teicoplanin (in 4 patients), and tigecycline (in 8 patients).