Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_167
Snippet: These results suggest the importance of considering the dietary content of Clfor KBr-treated dogs and may also assist with the selection of KBr doses and appropriate diets by clinicians for dogs treated with KBr. Canine central nervous system tumors can develop deeply within the brain parenchyma, precluding surgical resection and limiting therapeutic options. PAC-1 is a novel, blood-brain barrier penetrant, pro-apoptotic small molecule activator .....
Document: These results suggest the importance of considering the dietary content of Clfor KBr-treated dogs and may also assist with the selection of KBr doses and appropriate diets by clinicians for dogs treated with KBr. Canine central nervous system tumors can develop deeply within the brain parenchyma, precluding surgical resection and limiting therapeutic options. PAC-1 is a novel, blood-brain barrier penetrant, pro-apoptotic small molecule activator of procaspase-3 (PC-3), with orphan drug status for the treatment of human glioblastoma multiforme. PC-3 is frequently overexpressed in malignantly transformed tissues, providing an opportunity to selectively induce apoptosis in cancer cells with dysregulated upstream apoptotic circuitry. This study evaluates the in vitro activity of PAC-1 against a panel of brain tumor cells, and the feasibility of combining PAC-1 with conventional therapies in dogs with spontaneous brain cancer.
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