2017 ACVIM Forum Research Abstract Program

Akkermansia muciniphila PCR detection suggested successful gastrointestinal transit following oral supplementation in dogs, with an effect on gastrointestinal epithelium based on plasma cytokeratin-18 alterations. Further study is needed to determine impact in dogs with naturally occurring disease. Dysbiosis is thought to play a major role in the pathogenesis of intestinal disease. Treatment of intestinal disease may involve the use of antimicrobials, but their effects on the microbiota are not fully understood and several antibiotics have been shown to promote dysbiosis. The aim of this study was to prospectively evaluate the impact of tylosin administration on the fecal microbiota of healthy dogs.