2017 ACVIM Forum Research Abstract Program

Expression of cell surface avb3, and a3b1integrin in canine glioma cells was demonstrated using integrin specific peptide targeting, consistent with human cell lines and expression in dog tumour samples. Importantly, these integrin surface markers are also expressed in cell derived exosomes. Characterization of LXW7 and LXY30 binding exosomes in CSF and serum is therefore a rational strategy to define accessible biomarkers for gliomas in vivo. Meningitis, meningoencephalitis, and meningoencephalomyelitis (M/ME/MEM) are inflammatory conditions which may be of immune or infectious origins. A perceived increase in these conditions at a specialty referral practice led to two investigative studies. The first study was a retrospective survey of MRI diagnoses made during a 3-year period (2013) (2014) (2015) to assess increased prevalence and/or temporal trends. The second study was a 7-month prospective study of possible immune or infectious causes of M/ME/ MEM diagnosed at the practice.