Selected article for: "cell model and model cell toxicity"
Author: Samantha N. Davis; Patricia Wu; Esra D. Camci; Julian A. Simon; Edwin W Rubel; David W. Raible
Title: Chloroquine Kills Hair Cells in Zebrafish Lateral Line and Murine Cochlear Cultures: Implications for Ototoxicity
  • Document date: 2020_4_16
    • ID: 8uujhk5a_1
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.041731 doi: bioRxiv preprint Total hair cells remaining were compared to counts of the same neuromasts of untreated 162 fish or untreated cochlear cultures to calculate the percentage of hair cells remaining. Hair 163 cell survival was then related to concentration of chloroquine used in incubation. As hydroxychloroquine is often used .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.041731 doi: bioRxiv preprint Total hair cells remaining were compared to counts of the same neuromasts of untreated 162 fish or untreated cochlear cultures to calculate the percentage of hair cells remaining. Hair 163 cell survival was then related to concentration of chloroquine used in incubation. As hydroxychloroquine is often used to replace chloroquine in clinical settings, 183 these two drugs were compared for relative hair cell toxicity. Both drugs showed dose-184 dependent hair cell loss ( Figure 2 ). Hydroxychloroquine showed slightly more toxicity than 185 chloroquine (F=4.774, p=0.03; two-way ANOVA). These results demonstrate that both 186 clinically-relevant chloroquine drugs show hair cell toxicity in the zebrafish model. 187

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