2017 ACVIM Forum Research Abstract Program

In summary, the Ki-67/CD3 index is significant upregulated in the LP, specifically in the crypt area of IBD dogs indicating a metabolically active region. In conclusion, Ki-67/CD3 could be a useful marker for canine IBD activity. In people, lower esophageal sphincter (LES) disorders causing functional obstruction have been identified as rare causes of megaesophagus (ME). Obstructive LES disorders have been identified in dogs but lack clear diagnostic criteria. Because these conditions may respond to targeted therapy, correct diagnosis is critical. Videofluoroscopic swallow study (VFSS) is the gold-standard for the diagnosis of dysphagia in dogs. Our objective was to characterize VFSS features of LES achalasia-like syndrome and dyssynchrony in dogs. We hypothesized that LES achalasia-like syndrome (LES-AS) and LES dyssynchrony (LES-D) could be distinguished from each other and normal dogs using standardized VFSS criteria.