2017 ACVIM Forum Research Abstract Program

In conclusion, physiologic tricuspid and pulmonic regurgitations are common findings in healthy adult tigers. The echocardiographic measurements obtained during this study can be used as references for future examinations in adult tigers. The effects of medetomidine on these measurements, specifically the left ventricular internal dimension at end-diastole and interventricular septum thickness at end-systole, should be taken into account. Platelet function testing may be useful to identify if clopidogrel resistance occurs in cats. Plateletworks Ã’ (PW) consistently detects clopidogrel effect in normal cats using ADP as agonist. In canine PW studies, arachidonic acid (AA) is as useful an agonist as ADP to detect clopidogrel effect, but there are no data for cats. Platelet Function Analyzer Ã’ (PFA) inconsistently detects clopidogrel effect in normal cats using the collagen-ADP cartridge. This also occurs in humans, prompting development of the INNOVANCE Ã’ P2Y cartridge, which consistently detects clopidogrel effect in humans and dogs. The objective of this study was to investigate PW-AA and PFA-P2Y in cats. Nine normal cats and 13 cats with cardiovascular diseases were studied. All had normal hematocrits and platelet counts. Blood samples were collected by jugular venipuncture. The 9 normal cats showed PW-AA %Aggregation (%Agg) = 83-97% and PFA-P2Y Closure Time (CT) = 38-111 seconds. For cats with cardiovascular diseases (one or both tests performed): a) 7 cats already receiving clopidogrel: PW-AA %Agg = 4-19% (n = 3) and PFA-P2Y CT >300 seconds (n = 6). b) 6 cats prior to starting clopidogrel: PW-AA %Agg = 21-96% (n = 5) and PFA-P2Y CT = 50-118 seconds (n = 3). For 3 of these 6 cats one or both tests were repeated while receiving clopidogrel: PW-AA % Agg = 0-12% (n = 3) and PFA-P2Y CT >300 seconds (n = 1). For both tests, differences between normal cats and cats being treated with clopidogrel were significant (P < 0.05). PW with AA agonist and PFA with P2Y cartridge may be highly sensitive to detect clopidogrel effect in cats. Fujii 1 , H. Sunahara 1 , K. Sugimoto 1 , T. Uehara 1 , Y. Wakao 2 . 1 Azabu University, Sagamihara, Kanagawa, Japan, 2 Azabu University, Sagamihara-shi, Kanagawa, Japan