Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_212
Snippet: The normalised gene expression of SSTR1-5 in acromegalic cats was SSTR1 = SSTR5 > SSTR2 vs SSTR5 = SSTR1 = SSTR2 in control cats. SSTR3 and SSTR4 were undetectable. Expression of SSTR1, SSTR2 and SSTR5 were upregulated in acromegalics vs controls (SSTR1: P = 0.006, SSTR2: P = 0.005, SSTR5: pSSTR1 increased x9 [95% CI 4 -12], SSTR2 increased x6.5 [95% CI 2.5 -8.5] and SSTR5 increased x4 [95% CI 2 -4]. D2R gene expression was not significantly diff.....
Document: The normalised gene expression of SSTR1-5 in acromegalic cats was SSTR1 = SSTR5 > SSTR2 vs SSTR5 = SSTR1 = SSTR2 in control cats. SSTR3 and SSTR4 were undetectable. Expression of SSTR1, SSTR2 and SSTR5 were upregulated in acromegalics vs controls (SSTR1: P = 0.006, SSTR2: P = 0.005, SSTR5: pSSTR1 increased x9 [95% CI 4 -12], SSTR2 increased x6.5 [95% CI 2.5 -8.5] and SSTR5 increased x4 [95% CI 2 -4]. D2R gene expression was not significantly different between tumorous or normal pituitary tissue; within the hypersomatotropism group D2R exhibited a moderate negative correlation with pituitary volume (r = -0.62, P < 0.01, Rsquare 0.39).
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