Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_228
Snippet: A single institution prospective single arm observational study was conducted. Dogs naive of any endocrine treatment suffering from pituitary hyperadrenocorticism diagnosed by standard laboratory and imaging tests were irradiated with 6 MV LINAC using Volumetric Modulated Arc Therapy with a dose of 38 Gy delivered in 10 fractions on alternated days basis. Concomitant administration of trilostane were started. Tumor and endocrine response were eva.....
Document: A single institution prospective single arm observational study was conducted. Dogs naive of any endocrine treatment suffering from pituitary hyperadrenocorticism diagnosed by standard laboratory and imaging tests were irradiated with 6 MV LINAC using Volumetric Modulated Arc Therapy with a dose of 38 Gy delivered in 10 fractions on alternated days basis. Concomitant administration of trilostane were started. Tumor and endocrine response were evaluated by repeated MRI of pituitary and adrenal glands at 0-2-4-6-8-12-18-24 months. Basal and ACTH-stimulated cortisol were serially measured and the dose of trilostane to achieve eucortisolism was recorded.
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