Selected article for: "chloroquine drug and hair cell"
Author: Samantha N. Davis; Patricia Wu; Esra D. Camci; Julian A. Simon; Edwin W Rubel; David W. Raible
Title: Chloroquine Kills Hair Cells in Zebrafish Lateral Line and Murine Cochlear Cultures: Implications for Ototoxicity
  • Document date: 2020_4_16
    • ID: 8uujhk5a_3
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.041731 doi: bioRxiv preprint two sets of experiments to test this idea. Function of the mechanotransduction channel 192 was assessed through quantification of FM1-43X uptake after pre-treatment with 193 chloroquine at doses that cause maximal hair cell death. Fish were also treated with 194 benzamil, a MET channel blocker known to bloc.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.041731 doi: bioRxiv preprint two sets of experiments to test this idea. Function of the mechanotransduction channel 192 was assessed through quantification of FM1-43X uptake after pre-treatment with 193 chloroquine at doses that cause maximal hair cell death. Fish were also treated with 194 benzamil, a MET channel blocker known to block drug uptake ( implying that chloroquine uptake is rapid and affects hair cells soon after they are exposed. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.041731 doi: bioRxiv preprint and organ of Corti, especially to outer hair cells (Hennebert and Fernández, 1959). 251

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