2017 ACVIM Forum Research Abstract Program

In DD, tonicity (315 vs 311 mOsm/L; P = 0.02) and GLU (295 vs 110 mg/dL; P = 0.0001) were elevated while NA and CL were decreased compared with NDD. HT (tonicity > 315 mOsm/L) occurred more frequently in DD (45.9% vs 31.1% for NDD). The dMCV, a marker for HT, was significantly increased in DD (3.9 vs 1.7 fL for NDD). Increased dMCV predicted an elevated fructosamine (> 450 lmol/L) with 82.6% sensitivity and 42.8% specificity. The results show that stable, insulin-treated diabetic dogs frequently have HT and that GLU is the major osmole that contributes to HT in DD. An increase in dMCV is a modest predictor for serum fructosamine, suggesting the latter is an indirect marker for hypertonicity in DD. In conclusion, dogs with moderate/poor glycemic control show evidence of persistent HT, although additional studies are needed to investigate the role of persistent HT and its possible consequences for diabetic dogs. An imbalance in vitamin D status has recently been suggested to be associated with disease progression in humans with pancreatitis. To date, however, no studies have investigated the association between vitamin D status and acute pancreatitis (AP) in dogs. Therefore, the purpose of this study was to examine differences between the concentrations of serum 25-hydroxyvitamin D (25-[OH]D) in healthy dogs vs. AP dogs, and, if so, to determine the correlations between 25-(OH)D, ionized calcium (iCa), and C-reactive protein (CRP) levels.