Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_309
Snippet: Fifteen healthy dogs were randomized to 1 of 5 groups: aspirin 2 mg/kg/d (A), clopidogrel 2-3 mg/kg/d (C), prednisone 2 mg/kg/ d (P) or combined prednisone with aspirin (PA) or prednisone with clopidogrel (PC) therapy PO for 28 days. Platelet count, PFA-100 Ò analysis (collagen/epinephrine or collagen/ADP as appropriate), and endoscopy were performed at baseline, 14 days (platelet tests only), and 28 days. The presence of ≥15 hemorrhages, ≥5.....
Document: Fifteen healthy dogs were randomized to 1 of 5 groups: aspirin 2 mg/kg/d (A), clopidogrel 2-3 mg/kg/d (C), prednisone 2 mg/kg/ d (P) or combined prednisone with aspirin (PA) or prednisone with clopidogrel (PC) therapy PO for 28 days. Platelet count, PFA-100 Ò analysis (collagen/epinephrine or collagen/ADP as appropriate), and endoscopy were performed at baseline, 14 days (platelet tests only), and 28 days. The presence of ≥15 hemorrhages, ≥5 punctate erosions, ≥1 invasive erosion, or ≥1 ulcer was considered clinically-significant bleeding. Dogs were categorized as antiplatelet responders if closure times were >300 sec (aspirin) or increased >30% compared to baseline (clopidogrel). Gastrointestinal bleeding and antiplatelet responder status were compared among groups by Fisher's exact test; P < 0.05 was considered significant.
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