Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_321
Snippet: Vomiting and regurgitation occur commonly following PEG administration in dogs with naturally occurring large intestinal diseases. Maropitant was not superior in preventing these. PEG administration technique may be important. Recently, novel pore-forming toxins designated as NetE and NetF were identified in a Clostridium (C.) perfringens type A strain isolated from a dog with acute hemorrhagic diarrhea. Poreforming toxins, which have cytotoxic a.....
Document: Vomiting and regurgitation occur commonly following PEG administration in dogs with naturally occurring large intestinal diseases. Maropitant was not superior in preventing these. PEG administration technique may be important. Recently, novel pore-forming toxins designated as NetE and NetF were identified in a Clostridium (C.) perfringens type A strain isolated from a dog with acute hemorrhagic diarrhea. Poreforming toxins, which have cytotoxic activity, could be responsible for the necrotizing mucosal lesions typically present in dogs with acute hemorrhagic diarrhea syndrome (AHDS). Thus, this study aimed to determine the prevalence of C. perfringens encoding netE and netF in feces of dogs with AHDS and to evaluate any association between severity of clinical signs and the presence of these toxin genes.
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