2017 ACVIM Forum Research Abstract Program

The results suggest that overgrowth of C. perfringens type A strains encoding for netE and netF is not a general sequel of acute hemorrhagic diarrhea, since these genes were not detected in dogs with CPV infection. A primary pathogenic role of these toxins in AHDS is likely. Peripheral eosinophilia has limitations as a marker of eosinophil-mediated disease. The measurement of 3-bromotyrosine (3-BrY) in serum has been reported to serve as a monitoring tool for eosinophil-mediated diseases in humans. In a previous study, we showed serum 3-BrY concentrations to be increased in dogs with eosinophilic gastroenteritis as well as lymphocytic-plasmacytic enteritis. However, serum 3-BrY concentrations have not previously been evaluated more specifically in dogs with food-responsive diarrhea (FRD) and steroid-responsive diarrhea (SRD). Therefore, the objectives of this study were to compare peripheral eosinophil counts in dogs with FRD, SRD, and healthy control dogs and to evaluate and compare serum 3-BrY concentrations in dogs with FRD, SRD, and healthy control dogs.