2017 ACVIM Forum Research Abstract Program

At baseline, dogs with AHDS exhibited decreased fecal phytosterol (i.e., b-sitosterol, campesterol, sitostanol, fucosterol, and stigmasterol, all P < 0.001), increased cholesterol (P < 0.001), and increased fatty acid (i.e., stearic, erucic, gondoic, palmitic, and a-linolenic, all P < 0.001) concentrations when compared to healthy control dogs. There were no statistically significant differences in any of the compounds between FRD and SRD dogs at baseline. There were several significant differences observed between dogs with SRD and healthy control dogs at baseline: decreased bsitosterol, sitostanol, campesterol, and fucosterol (P < 0.001, P < 0.001, P = 0.002, and P = 0.013, respectively), and increased erucic, gondoic, and stearic acids (P = 0.008, P = 0.012, and P = 0.038, respectively). However, at the 2-3 months follow-up, several sterols were altered between dogs with SRD and FRD: sitostanol, b-sitosterol, and fucosterol were decreased in SRD (P < 0.001, P = 0.004, and P = 0.033, respectively), and a-linolenic, erucic, and gondoic acids were also decreased in dogs with SRD (P < 0.001, P = 0.004, and P = 0.004). At the 2-3 months follow-up campesterol, stigmasterol, cholesterol, stearic acid, and palmitic acid were no longer significantly different between dogs with AHDS and healthy control dogs.