2017 ACVIM Forum Research Abstract Program

Results of this study suggest that the mucosal microbiota in the colon of dogs with SRE is different from that of CD. Although clinical signs improved, colonic mucosal dysbiosis was still present after 4 months of treatment. The canine pancreatic lipase immunoreactivity (cPLI) concentration is considered the most specific biomarker for the diagnosis of canine pancreatitis. In one report, 4 weeks of oral administration of prednisone (2.2 mg/kg/day) to six healthy dogs had no significant effect on the serum cPLI concentration (Steiner et al., 2009) . The aim of this study was to determine the effect of highdose prednisolone (4 mg/kg/day) on the pancreatic tissue and serum cPLI concentration in healthy dogs. Six healthy beagles received prednisolone (4 mg/kg/day subcutaneously) for 2 or 3 weeks. Measurement of the cPLI concentration and ultrasonographic examination of the pancreas were performed before and after treatment. Laparoscopic biopsy of the liver and right pancreatic lobe was also performed before and after treatment. The serum cPLI concentration was compared before and after treatment using the Wilcoxon signed-rank test. The serum cPL concentration was significantly higher after than before treatment. The post-treatment cPLI concentration was classified as normal (≤200 lg/L) in five dogs and abnormal (≥400 lg/L) in one dog.