2017 ACVIM Forum Research Abstract Program

Further studies are needed to determine whether some of the proteins identified may prove useful as a biomarker of chronic hepatitis in dogs. Canine chronic hepatitis can present a diagnostic challenge with various etiologies leading to similar clinical signs and laboratory findings. The histopathological assessment of a liver biopsy specimen is often required for a definitive diagnosis to be made and few prognostic markers exist. The emerging science of metabolomics is used to detect changes in endogenous low molecular weight metabolites in biological samples and offers the possibility of identifying non-or minimally-invasive surrogate markers of disease. The objective of this study was to characterize metabolite changes in the urine of dogs with chronic hepatitis using an untargeted methodology.