Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_499
Snippet: Six-hundred-and-fifty-one genes (1,136 transcripts) were differentially expressed in dogs with chronic hepatitis. A connection with hepatic fibrosis or related pathways was identified for 190 of these genes (269 transcripts). One-hundred-and-sixty-five of these genes (222 transcripts) were upregulated and 25 (47 transcripts) were downregulated. They were grouped into the following subcategories: extracellular matrix degradation, extracellular mat.....
Document: Six-hundred-and-fifty-one genes (1,136 transcripts) were differentially expressed in dogs with chronic hepatitis. A connection with hepatic fibrosis or related pathways was identified for 190 of these genes (269 transcripts). One-hundred-and-sixty-five of these genes (222 transcripts) were upregulated and 25 (47 transcripts) were downregulated. They were grouped into the following subcategories: extracellular matrix degradation, extracellular matrix organization, hepatic stellate cell activation, apoptosis, detoxification of reactive oxygen species, and components of fibrotic mechanisms mentioned in the human literature.
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