2017 ACVIM Forum Research Abstract Program

These results demonstrate that Efm inhibits Tf growth. Pretreatment of intestinal epithelial cells with Efm, but not treatment at the time of Tf infection, inhibits adhesion of Tf to intestinal epithelial cells in vitro. Studies investigating other Enterococcus spp, as well as multi-strain probiotics, in combination with ronidazole are warranted. Gammaherpesviruses (GHVs) are members of an emerging subfamily of the Herpesviridae. The two major human GHVs, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are clinically important pathogens because those viruses possess tumorigenesis potential especially in immune-compromised patients. In feline practice, we often experience tumor cases, especially lymphomas. Feline leukemia virus (FeLV) was a major cause for the development of lymphoma in the past days, however, the majority of lymphoma cases are shifting to FeLVfree cats. But the mechanism of tumorigenesis in these spontaneously developed lymphomas has not been well understood. Under this situation, GHV became a candidate which explain the lymphomagenesis in domestic cats. Recent study identified a novel GHV in domestic cats (Felis catus GHV, FcaGHV), and epidemiological surveys found that FcaGHVs are distributing in several countries including the United States, Australia, Singapore, Germany and Austria. In the present study, a nation-wide molecular epidemiological study was conducted to investigate the prevalence of GHVs in Japan.