2017 ACVIM Forum Research Abstract Program

Our study suggests that, regardless of the transfusion rate, the microaggregate filter does not alter the fragility of the canine RBC, but may alter the morphology. RBC morphology alterations could contribute to a decrease in RBC survival when administrating blood via a syringe pump. Circulating platelet microparticles (PMP) are subcellular vesicles released from platelet and possibly megakaryocyte membranes. In people, altered PMP concentrations are associated with pro-thrombotic, inflammatory, neoplastic and cardiovascular conditions, but only few canine studies exist. Blood-processing pre-analytically influences the PMP concentration. The study purpose was to analytically validate PMP quantification in dogs with a perspective of clinical application.