2017 ACVIM Forum Research Abstract Program

In agreement with previous studies, healthy Greyhounds had significantly higher hematocrits and lower platelet counts. Based off of the TEG tracings, Greyhounds appeared significantly hypocoagulable (decreased MA) and hyperfibrinolytic (increased LY30, LY60, and decreased CL30, CL60). Future studies should investigate whether hyperfibrinolysis contributes to the propensity to bleed in Greyhounds. The platelet aggregometry results were significantly lower for both agonists in Greyhounds as compared to Beagles which could be erroneously interpreted as decreased platelet function in this breed. Therefore, just as hematocrit and platelet count can affect TEG tracings, the same considerations should be applied to whole blood impedance platelet aggregometry. Both the high hematocrit and low platelet counts in healthy Greyhounds can potentially contribute to lower aggregometry readings due to suspected in vitro effects rather than reflecting true in vivo effects since other studies have demonstrated normal platelet function in Greyhounds. Therefore, it is not recommended to compare whole blood impedance platelet aggregometry measurements of Greyhounds to non-Greyhounds. Subject-based or population-based reference intervals should be established in this breed for accurate interpretation of results. The objectives of this study were to compare thawing times between a 37°C warm water bath (WWB), running water bath (RWB), and Plasmatherm and compare hemostatic protein function in canine fresh frozen plasma (FFP) thawed with WWB or Plasmatherm.