Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_518
Snippet: In a companion abstract, we demonstrate the mucosal immune stimulatory properties of an LTLC-based immune stimulant administered to healthy cats. Therefore, taken together with the in vitro findings presented here, these results suggest that LTLC may be used as an effective non-specific immune stimulant for induction of anti-viral and anti-bacterial immunity in cats. Tumor necrosis factor-alpha (TNF-a) is a cytokine released mainly by macrophages.....
Document: In a companion abstract, we demonstrate the mucosal immune stimulatory properties of an LTLC-based immune stimulant administered to healthy cats. Therefore, taken together with the in vitro findings presented here, these results suggest that LTLC may be used as an effective non-specific immune stimulant for induction of anti-viral and anti-bacterial immunity in cats. Tumor necrosis factor-alpha (TNF-a) is a cytokine released mainly by macrophages in response to contact with infectious agents, tissue injury, tumor growth, and autoimmune conditions. Thus, measurement of TNF-a warrants evaluation as a diagnostic and prognostic marker in cats with inflammatory diseases. However, currently no analytically validated assay is commercially available for the measurement of this cytokine in cats. The aim of this study was to develop and analytically validate an electrochemiluminescent immunoassay for the measurement of TNF-a in cat serum.
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