2017 ACVIM Forum Research Abstract Program

Seven beagles that were experimentally infected with E. canis and administered doxycycline at 10 mg/kg, PO daily for 4 weeks were included in this study. Three of the dogs were also infected with Anaplasma platys and Babesia vogeli and were administered two doses of imidocarb at 6.6 mg/kg, IM 2 weeks apart prior to enrollment. Each dog was administered prednisolone (Dose range 0.94 -1.25 mg/kg, PO, q12 hours) in conjunction with cyclosporine whose dosages were adjusted based on the trough levels (Final dose range 5.3 -8.3 mg/kg, PO, q12 hours) for 6 weeks. Clinical signs (fever, lethargy, and anorexia), complete blood count (CBC), polymerase chain reaction (PCR) for DNA of E. canis, A. platys, and B. vogeli in blood, anti-E.canis indirect fluorescent antibodies (IFA) titers, and flow cytometry for antiplatelet antibodies were monitored.