2017 ACVIM Forum Research Abstract Program

The use of FLK as a continuous infusion at dosage of 0.08, 30 and 15 lg/kg/min in patients anesthetized with Isoflurane generated statistically significant changes in the blood pH and body temperature (P < 0.05). Regarding the cardiovascular and hemodynamic variables, there were no statistically significant difference changes (P > 0.05) at the different time points although it was possible to observe a tendency to improve the tissue perfusion and hemodynamic stability. Keywords: Anesthesia, blood gases, cardiac output, IÅšTAT, multimodal analgesia. Mycophenolic acid, the active form of mycophenolate mofetil (MMF), is effective in controlling dysregulated lymphocyte responses associated with immune-mediated diseases. This drug has been shown to be promising for the treatment of multiple autoimmune diseases in dogs and cats. In humans, dose optimization and plasma drug concentration monitoring (TDM) are recommended in order to maximize the MPA effect, particularly in patients that require sustained immunosuppression. In humans, MPA is a highly protein bound drug (~97%). It is recommended to monitor free drug plasma concentration, as the free (unbound) MPA correlates with its immunosuppressive effect. It is likely that dogs and cats would also need TDM and optimization of dosage regimens. However, the extent of MPA plasma protein binding in dogs and cats are unknown. Importantly, the extent of MPA protein binding cannot be extrapolated from other species due to inherent differences in albumin structure and drug binding capacity.