Selected article for: "ASA concentration and oral administration"
Title: 2017 ACVIM Forum Research Abstract Program
  • Document date: 2017_6_15
    • ID: ri2w5iby_685
    Snippet: The objectives of our study were to determine whether the ASA concentration needed to cause 50% inhibition of platelet aggregation (IC50) in vitro in healthy dogs was predictive of the IC50 value measured in the same dogs after administration of oral aspirin (in vivo IC50). Furthermore, we wanted to evaluate whether the addition of fluoride, known to cause non-specific esterase inhibition, altered the concentrations of ASA or its metabolite, sali.....
    Document: The objectives of our study were to determine whether the ASA concentration needed to cause 50% inhibition of platelet aggregation (IC50) in vitro in healthy dogs was predictive of the IC50 value measured in the same dogs after administration of oral aspirin (in vivo IC50). Furthermore, we wanted to evaluate whether the addition of fluoride, known to cause non-specific esterase inhibition, altered the concentrations of ASA or its metabolite, salicylic acid (SA), in blood samples collected after oral aspirin administration.

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