2017 ACVIM Forum Research Abstract Program

Erythema of the inner pinna was a common finding in multiple cats at various time points with one cat showing an excoriation of one ear on day 5 which subsequently healed uneventfully. One cat with CKD exhibited vomiting between study days 16 and 21 and recovered without treatment. The same cat showed intermittent bouts (2-3 sec.) of spasms and ataxia with tail curled over the back on day 20 only. All cats gained a significant amount of weight between Day 0 and Day 28 (P = 0.016). Blood pressure was analyzed in the healthy cats at a single time point and there was no significant difference compared to baseline at any time point. Hematology and serum chemistry showed no clinically significant changes in either apparently healthy cats or the two cats with CKD. There were no clinically significant changes in cardiac findings. There was no significant difference in behavior scores between the beginning and end of the study despite a 59 dose of mirtazapine.