2017 ACVIM Forum Research Abstract Program

Forty-one client-owned dogs with CMVD were included. All the dogs underwent physical examination, blood works, radiographs, abdominal ultrasound, urinalysis, electrocardiogram, and echocardiography. Dogs were categorized according to American College of Veterinary Internal Medicine (ACVIM) consensus statement and International Renal Interest Society (IRIS) staging system. 2D, M-mode, and Doppler examinations were performed for conventional echocardiography. Using STE, strains of circumferential, radial, and longitudinal motions, LV twist, LA volume, and LA strain were assessed. Systolic twist increased to moderate stage (ACVIM C class) and decreased in severe stage (ACVIM D class). Dogs in advanced stage had increased circumferential and radial strain, whereas decreased longitudinal strain compared with earlier stages. LA maximal and minimal volume increased, and left atrial active emptying index, LA-FACact and peak LA strain rate during atrial contraction were decreased with severity. Higher concentrations of serum creatinine and serum urea were found in ACVIM class D. IRIS stage had statistically significant correlation with ACVIM class and several echocardiographic variables including early diastolic untwisting rate and E/A.