2017 ACVIM Forum Research Abstract Program

The IV LiCl bolus was well tolerated and side effects were not observed. The SEA showed acceptable linearity, R 2 = 0.9752; inter-day CV, 2.5%; and recovery, 96.3%. Both non-compartmental and compartmental analyses (traditional two-stage and nonlinear mixed-effects [NLME] modeling) were performed. Geometric mean values of non-compartmental parameters were: plasma Li + concentration at time zero, 2.19 mM; terminal elimination halflife, 1541 min; area under the plasma concentration-time curve from time zero to infinity, 550 mM min; clearance, 0.273 mL/min/ kg; mean residence time, 1875 min; and volume of distribution at steady state, 511 mL/kg. Results of the traditional two-stage analysis showed good agreement with the NLME modeling approach. Bland-Altman analyses demonstrated poor agreement between the SEA and ICP-MS methods over the therapeutic Li + concentration range (95% limits of agreement = 0.14 AE 0.13 mM).