2017 ACVIM Forum Research Abstract Program

All cats developed AAGS. Vomiting was less in cats receiving a synbiotic, but the difference was not significant. Alpha and beta diversity changed significantly during treatment. Decreases in Actinobacteria (Bifidobacterium, Collinsella, Slackia), Bacteriodetes (Bacteroides), Lachnospiraceae (Blautia, Coprococcus, Roseburia), Ruminococcaceae (Faecilobacterium, Ruminococcus), and Erysipelotrichaceae (Bulleidia, [Eubacterium] ) and increases in Clostridiaceae (Clostridium) and Proteobacteria (Aeromonadales, Enterobacteriaceae) occurred, with incomplete normalization by days 631-633. Derangements in short-chain fatty acid, bile acid, indole, sphingolipid, polyamine and cinnaminic acid profiles occurred, some of which persisted through days 631-633 and differed between groups.