Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_457
Snippet: The positive dogs had significantly lower platelet counts but had evidence of activated platelets based on an increased MPV and MPM. There was evidence of decreased platelet function in the positive dogs but this could have been related to the degree of thrombocytopenia. The positive dogs also showed evidence of anti-platelet antibodies during infection. Overall, the positive dogs appeared hypercoagulable based on an increased MA, MRTG, and TG an.....
Document: The positive dogs had significantly lower platelet counts but had evidence of activated platelets based on an increased MPV and MPM. There was evidence of decreased platelet function in the positive dogs but this could have been related to the degree of thrombocytopenia. The positive dogs also showed evidence of anti-platelet antibodies during infection. Overall, the positive dogs appeared hypercoagulable based on an increased MA, MRTG, and TG and hypofibrinolytic based on a lower LY30, LY60 and higher CL30 and TMRL. The characteristics of hemostasis during experimental E. canis infection are complicated but platelet indices of activation and evidence of a hypercoagulable, hypofibrinolytic state may explain the lack of a bleeding phenotype in some dogs despite significant thrombocytopenia.
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