Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_66
Snippet: The histological examination confirmed the occurrence of degenerative myocardial changes ("fatty infiltration-degenerative type" and "attenuated wavy fiber type"), but also revealed a general increase in interstitial cells. In addition, focal lesions were observed. These comprised accumulations of fibroblastlike cells, mild fibrosis and edema, with neovascularization and degenerating cardiomyocytes. The majority of interstitial cells appeared to .....
Document: The histological examination confirmed the occurrence of degenerative myocardial changes ("fatty infiltration-degenerative type" and "attenuated wavy fiber type"), but also revealed a general increase in interstitial cells. In addition, focal lesions were observed. These comprised accumulations of fibroblastlike cells, mild fibrosis and edema, with neovascularization and degenerating cardiomyocytes. The majority of interstitial cells appeared to be of macrophage origin and were often found to express intracellular adhesion molecule (ICAM-1), transforming growth factor (TGF)-b and vascular endothelial growth factor, which also cardiomyocytes expressed frequently. The transcription of ICAM-1, matrix metalloproteinase (MMP)-2, tissue inhibitor of MMP (TIMP)-1, TIMP-2, lysyl oxidase and tumor necrosis factor (TNF)-a was significantly increased, and cardiomyocytes were shown transcribe most relevant markers.
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