2017 ACVIM Forum Research Abstract Program

In conclusion, PMP concentrations were quantified reliably in WB with acceptable analytical precision, suggesting an application in clinical settings. Plasma PMP concentrations were invalid or unobtainable due to DL overlap or hemolysis and/or lipidemia, respectively. Cardiogenic embolism (CE) in cats is a devastating condition primarily associated with cardiomyopathy. Hypercoagulability may pose a risk for thrombus formation; however, no single test can predict development of CE. Platelet microparticles (PMP) are subcellular vesicles released from platelet membranes and are associated with thrombosis in humans. The purpose of this study was to: i) analytically validate flow cytometric PMP quantification in cats and ii) in a pilot study, evaluate the concentration of procoagulant PMP in healthy cats and cats with cardiomyopathy.