2017 ACVIM Forum Research Abstract Program

Thirty-one dogs, of the targeted enrollment of 34, have completed the study. The median rGSH in the liver, plasma, and erythrocytes were 5.78 mM, 3.90 lM, and 1.88 mM, respectively. No correlations were found between liver rGSH and erythrocyte rGSH, vitamin E, or 8-IsoP. There was a modest negative correlation between liver and plasma rGSH (q -0.40; P 0.043). Dogs with liver disease had significantly higher urine 8-IsoP compared with healthy controls (5885 vs. 2980 pg / mg Cr; P < 0.0001). The initial results of this study demonstrate that in dogs with naturally occurring liver disease only plasma rGSH correlates with liver rGSH, albeit negatively. In addition, dogs with naturally occurring liver disease have evidence of increased systemic oxidative stress compared to healthy controls. Canine cholangitis appears to be more common than previously thought; yet our understanding of the disease remains incomplete. The study aim was therefore to describe a population of dogs with biopsy confirmed cholangitis.