Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_611
Snippet: Sixteen healthy lean adult beagles (2-8 years) with ideal body weight (BW) (average 11.39 AE 1.76 kg) and ideal body condition scores (BCS) (range 4-5/9, median: 4/9) were equally divided into a control group (group C) and a treatment group (group T), based on age and sex. After four weeks adaptation to a commercial adult maintenance diet, group T received 1.3 9 maintenance energy requirements to induce weight gain for 47 weeks, whereas group C w.....
Document: Sixteen healthy lean adult beagles (2-8 years) with ideal body weight (BW) (average 11.39 AE 1.76 kg) and ideal body condition scores (BCS) (range 4-5/9, median: 4/9) were equally divided into a control group (group C) and a treatment group (group T), based on age and sex. After four weeks adaptation to a commercial adult maintenance diet, group T received 1.3 9 maintenance energy requirements to induce weight gain for 47 weeks, whereas group C was fed to maintain an ideal BW and BCS for 47 weeks. All dogs were weighed and BCS was assessed on a weekly basis. At the end of the adaptation (week 0) and at week 47, systolic blood pressure; serum urea, creatinine, and albumin; urinary specific gravity, urinary protein:creatinine ratio (UPC) were measured. Glomerular filtration rate (GFR) was measured by plasma clearance of exoiohexol after an intravenous bolus injection of iohexol (Omnipaque 300 Ã’ , 64.7 mg/kg BW). While sedated (butorphanol, 0.04 ml/kg), CEUS of the left kidney was performed using a bolus injection with Sonovue Ã’ . Time intensity curves reflecting tissue perfusion were generated based on manually drawn region of interests on the renal cortex and medulla. Perfusion parameters (rise/fall time, area under curve (AUC), time to peak, wash-in/out rate (WiR/WoR), wash-in/out AUC, wash-in perfusion index (WiPI), mean transit time, and peak enhancement (PE)) were calculated and evaluated. Parametric and non-parametric tests were used to compare groups and paired data with significance set at P < 0.05.
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