2017 ACVIM Forum Research Abstract Program

Non-azotemic cats < 1.5 years of age had moderate alpha-enolase expression in tubular epithelium (median score = 2; range 2 -3) but staining was absent to mild in glomeruli (median score = 1; range 0 -2). In contrast, alpha-enolase expression was moderate to high in tubular epithelium (median score = 2; range 1.95 to 2.05) and glomeruli (median score = 2; range 1.8 to 2.6) in nonazotemic cats > 10 years of age. Lastly, evaluation of kidneys of cats with CKD showed that alpha-enolase expression was decreased in tubules that were degenerative or atrophic (median score = 1; range 0 -3), similar to the other groups of cats in normal tubules (median score = 2; range 1-3), and moderate to highly expressed in glomeruli (median score = 2; range 0-3). While no statistical difference was found between tubular immunoreactivity scores, there was a significant difference between glomerular immunoreactivity scores between non-azotemic cats > 10 years of age and non-azotemic cats < 1.5 years of age (P = 0.04) and CKD cats and non-azotemic cats < 1.5 years of age (P = 0.009).